This PET/CT project has two primary aims:
Specific Aim 1: To measure the quantitative imaging characteristics of modern PET/CT scanners when presented with the task of measuring concentration of very small objects (4mm-10mm diameter) using longer-duration, limited axial spatial extent acquisitions.
Specific Aim 2: To assess the impact of advanced (Time of Flight and Point-Response-Function enabled) reconstruction techniques on quantitation and detection of these very small objects under various:
1. Reconstruction scenarios
2. Concentration ratios (to background)
3. Scan Duration